{"id":26461,"date":"2026-04-01T01:06:15","date_gmt":"2026-03-31T17:06:15","guid":{"rendered":"https:\/\/theplutustimes.com\/?p=26461"},"modified":"2026-04-01T01:06:20","modified_gmt":"2026-03-31T17:06:20","slug":"%e3%80%90%e9%bb%83%e9%87%91%e6%99%82%e4%bb%a3%e3%80%91%e5%86%8d%e5%89%b5%e5%a5%87%e8%b9%9f","status":"publish","type":"post","link":"https:\/\/theplutustimes.com\/?p=26461","title":{"rendered":"\u3010\u9ec3\u91d1\u6642\u4ee3\u3011\u518d\u5275\u5947\u8e5f"},"content":{"rendered":"\n

\u6620\u6069\u751f\u7269\uff089606\uff09\u696d\u7e3e\uff0cB\u4ed4\u8cfa\u4e0d\u8cfa\u9322\u662f\u5176\u6b21\u3002\u9019\u523b\u5b83\u662f2019\u5e74\u7684\u4fe1\u9054\u3002<\/p>\n\n\n\n

\u6574\u9ad4\u7d93\u71df\u696d\u7e3e<\/p>\n\n\n\n

\u2022 \u6536\u5165<\/strong>\uff1a2025 \u5e74\u5be6\u73fe\u6536\u5165\u4eba\u6c11\u5e63 18.52 \u5104\u5143\uff0c\u8f03 2024 \u5e74\u7684 19.41 \u5104\u5143\u540c\u6bd4\u4e0b\u964d 4.6%\uff0c\u4e3b\u8981\u56e0\u90e8\u5206\u91cc\u7a0b\u7891\u6536\u5165\u63a8\u9072\u81f3\u4e0b\u4e00\u5e74\u5ea6\uff1b\u6536\u5165\u7d55\u5927\u90e8\u5206\u4f86\u81ea\u8a31\u53ef\u53ca\u5408\u4f5c\u5354\u8b70\uff08\u4f54\u6bd4 99.86%\uff09\u3002<\/p>\n\n\n\n

\u2022 \u7814\u767c\u6295\u5165<\/strong>\uff1a2025 \u5e74\u7814\u767c\u958b\u652f\u4eba\u6c11\u5e63 8.38 \u5104\u5143\uff0c\u8f03 2024 \u5e74\u5fae\u589e 0.1%\uff0c\u57fa\u672c\u4fdd\u6301\u7a69\u5b9a\u3002<\/p>\n\n\n\n

\u2022 \u8cc7\u91d1\u5145\u8db3\u6027<\/strong>\uff1a\u516c\u53f8\u8868\u793a\u73fe\u6709\u8cc7\u91d1\u53ef\u6eff\u8db3 2026 \u5e74\u71df\u904b\u8cc7\u91d1\u53ca\u8cc7\u672c\u958b\u652f\u9700\u6c42\uff1bIPO \u52df\u8cc7\u6de8\u984d\u7d04 174.75 \u5104\u6e2f\u5143\uff0c\u622a\u81f3 2025 \u5e74\u5e95\u5df2\u52d5\u7528\u7d04 68.99 \u5104\u6e2f\u5143\uff0c\u5269\u9918\u8cc7\u91d1\u53ef\u652f\u6490\u672a\u4f86 2-4 \u5e74\u7814\u767c\u8207\u7d93\u71df\u8a08\u5283\u3002<\/p>\n\n\n\n

\u4e8c\u3001\u6838\u5fc3\u696d\u52d9\u8207\u7ba1\u7dda\u9032\u5c55<\/p>\n\n\n\n

\u622a\u81f3 2025 \u5e74\u5e95\uff0c\u516c\u53f8\u64c1\u6709 10 \u6b3e\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u7684 ADC \u7ba1\u7dda\uff0c\u5168\u7403\u81e8\u5e8a\u8a66\u9a57\u7d2f\u8a08\u5165\u7d44\u8d85 3200 \u4f8b\u60a3\u8005\uff0c\u50c5 2025 \u5e74\u4fbf\u65b0\u589e\u5165\u7d44\u8d85 1200 \u4f8b\uff0c\u5176\u4e2d\u7d04 50% \u4f86\u81ea\u7f8e\u570b\u3001\u6b50\u76df\u7b49\u4e2d\u570b\u5883\u5916\u5730\u5340\u3002<\/p>\n\n\n\n

\u7b2c\u4e00\u68af\u968a\u6838\u5fc3\u8cc7\u7522\u81e8\u5e8a\u7a81\u7834<\/p>\n\n\n\n

1. DB-1303\/BNT323\uff08\u5e15\u5eb7\u66f2\u59a5\u73e0\u55ae\u6297\uff0cHER2 ADC\uff09<\/strong><\/p>\n\n\n\n

o \u91dd\u5c0d HER2 + \u4e73\u817a\u764c\u7684\u4e2d\u570b 3 \u671f\u8a3b\u518a\u8a66\u9a57\u9054\u5230\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3b\u8981\u7d42\u9ede\uff0c\u5df2\u5411\u4e2d\u570b\u85e5\u76e3\u5c40 CDE \u63d0\u4ea4\u751f\u7269\u88fd\u54c1\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u3002<\/p>\n\n\n\n

o \u91dd\u5c0d HER2 \u8868\u9054\u5b50\u5bae\u5167\u819c\u764c\u7684\u6f5b\u5728\u8a3b\u518a\u968a\u5217\u5df2\u5b8c\u6210\u5165\u7d44\uff0c\u9810\u8a08 2026 \u5e74\u7372\u5f97\u76f8\u95dc\u6578\u64da\uff0c\u5408\u4f5c\u65b9 BioNTech \u8a08\u5283 2026 \u5e74\u5c31\u8a72\u9069\u61c9\u75c7\u5411\u7f8e\u570b FDA \u63d0\u4ea4\u6f5b\u5728 BLA\u3002<\/p>\n\n\n\n

2. DB-1311\/BNT324\uff08B7-H3 ADC\uff09<\/strong><\/p>\n\n\n\n

o \u8f49\u79fb\u6027\u53bb\u52e2\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08mCRPC\uff09\u9069\u61c9\u75c7\u66f4\u65b0\u6578\u64da\u4eae\u773c\uff0c146 \u4f8b\u591a\u7dda\u6cbb\u7642\u60a3\u8005\u7684\u4e2d\u4f4d\u653e\u5c04\u5b78\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08rPFS\uff0911.3 \u500b\u6708\u3001\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff0922.5 \u500b\u6708\uff0c\u5b89\u5168\u6027\u53ef\u63a7\u3002<\/p>\n\n\n\n

o \u5bae\u9838\u764c\u3001\u9251\u8010\u85e5\u5375\u5de2\u764c\uff08PROC\uff09\u9069\u61c9\u75c7\u5c55\u73fe\u512a\u7570\u7642\u6548\uff0c\u78ba\u8a8d\u5ba2\u89c0\u7de9\u89e3\u7387\uff08cORR\uff09\u5206\u5225\u9054 33.3%\u300158.3%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u5206\u5225\u70ba 86.7%\u300175.0%\u3002<\/p>\n\n\n\n

o \u91dd\u5c0d\u4e00\u7dda mCRPC \u7684\u5168\u7403 3 \u671f\u8a66\u9a57\u8a08\u5283\u65bc 2026 \u5e74\u555f\u52d5\u3002<\/p>\n\n\n\n

3. DB-1310\uff08HER3 ADC\uff09<\/strong><\/p>\n\n\n\n

o EGFR \u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001HR+\/HER2 – \u4e73\u817a\u764c\u9069\u61c9\u75c7\u5747\u516c\u4f48\u7a4d\u6975\u81e8\u5e8a\u6578\u64da\uff0ccORR \u5206\u5225\u9054 28.3%\u300150.0%\uff0c\u5b89\u5168\u6027\u53ef\u63a7\u3002<\/p>\n\n\n\n

o 2025 \u5e74\u5148\u5f8c\u7372\u5f97\u7f8e\u570b FDA \u5169\u9805\u5feb\u901f\u901a\u9053\u8a8d\u5b9a\uff0c\u5206\u5225\u5c0d\u61c9\u665a\u671f NSCLC\u3001HR \u967d\u6027 \/ HER2 \u9670\u6027\u4e73\u817a\u764c\u9069\u61c9\u75c7\u3002<\/p>\n\n\n\n

\u5176\u4ed6\u7ba1\u7dda\u8207\u6280\u8853\u5e73\u53f0\u9032\u5c55<\/p>\n\n\n\n

\u2022 DB-1305\/BNT325\uff08TROP2 ADC\uff09\u5728\u5375\u5de2\u764c\u3001\u4e09\u9670\u6027\u4e73\u817a\u764c\u9069\u61c9\u75c7\u5c55\u73fe\u826f\u597d\u7642\u6548\uff0c\u806f\u5408\u7642\u6cd5\u4e5f\u89c0\u5bdf\u5230\u65e9\u671f\u6297\u816b\u7624\u6d3b\u6027\u3002<\/p>\n\n\n\n

\u2022 DB-2304\uff08BDCA2 ADC\uff09\u91dd\u5c0d\u7cfb\u7d71\u6027\u7d05\u6591\u72fc\u7621\uff08SLE\uff09\u7684 1 \u671f\u81e8\u5e8a\u6578\u64da\u7a4d\u6975\uff0c2a \u671f\u5df2\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7d66\u85e5\uff0c\u662f\u5168\u7403\u7814\u767c\u9032\u5ea6\u9818\u5148\u7684\u540c\u985e\u7522\u54c1\u3002<\/p>\n\n\n\n

\u2022 DB-1324\uff08CDH17 ADC\uff09\u7372\u5f97\u7f8e\u570b FDA IND \u6279\u51c6\uff0c\u5168\u7403 1\/2 \u671f\u8a66\u9a57\u5df2\u555f\u52d5\u60a3\u8005\u62db\u52df\uff1b\u96d9\u7279\u7570\u6027 ADC \u7ba1\u7dda DB-1418\u3001DB-1419 \u5747\u9806\u5229\u63a8\u9032\u81e8\u5e8a\u968e\u6bb5\u3002<\/p>\n\n\n\n

\u2022 \u56db\u5927\u81ea\u7814 ADC \u6280\u8853\u5e73\u53f0\u6301\u7e8c\u8fed\u4ee3\uff0c\u65b0\u578b DUPAC \u5e73\u53f0\u516c\u4f48\u81e8\u5e8a\u524d\u6578\u64da\uff0c\u5c55\u73fe\u51fa\u514b\u670d\u5c0d Dxd \u53ca\u5176\u4ed6\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291\u8010\u85e5\u6027\u7684\u6f5b\u529b\u3002<\/p>\n\n\n\n

\u5168\u7403\u5408\u4f5c\u4f48\u5c40<\/p>\n\n\n\n

\u2022 \u8207 BioNTech \u7684\u6230\u7565\u5408\u4f5c\u6301\u7e8c\u6df1\u5316\uff0c3 \u6b3e\u6838\u5fc3 ADC \u8207 PD-L1xVEGF \u96d9\u7279\u7570\u6027\u6297\u9ad4\u7684\u806f\u5408\u7642\u6cd5\u5747\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7d66\u85e5\uff0c\u591a\u9805\u8a66\u9a57\u9810\u8a08 2026 \u5e74\u8b80\u51fa\u6578\u64da\u3002<\/p>\n\n\n\n

\u2022 \u8207GSK\u4e4b\u5408\u4f5c\uff1aGSK\u652f\u4ed8\u4e86\u9996\u4ed8\u6b3e3 \u5343\u842c\u7f8e\u5143\uff0c\u4e26\u540c\u610f\u652f\u4ed8\u984d\u5916\u7684\u9078\u64c7\u6b0a\u884c\u4f7f\u524d\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<\/p>\n\n\n\n

\u4ee5ADC\u540c\u696d\u79d1\u502b\u535a\u6cf0\u5546\u696d\u5316\u982d\u4e00\u5e74\u7684\u4f30\u503c\u4f86\u770b\uff0c\u4eca\u5e74\u4e0b\u534a\u5e74\u7b2c\u4e00\u96bb\u85e5\u7269\u7372\u6279\uff0c\u7b2c\u4e00\u76ee\u6a19\u662f100\u5104\u7f8e\u5143\u5e02\u503c\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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